MicroCell: Microsystems for Cell Engineering
Axes: Engineering for Health, Surfaces & Interfaces
Leaders: Atsushi SHIRAI (IFS, TU) & Jean-Paul RIEU (iLM, UCBL)
Participants: Kenichi FUNAMOTO (FRIS & CITE, TU), Remy FULCRAND (iLM, UCBL), Charlotte RIVIERE (iLM, UCBL)
In vivo, cells are submitted to various stimuli: chemical signals and gradients, hypoxia, shear stress, mechanical compression and confinement, rigidity and geometry of the surrounding tissues. All these stimuli are intermingled and play a role in the immune response, in the development of embryos, in stem cell fate, or in the development of pathologies such as cancer. Microsystems and microfluidic devices have now made it possible to envision solutions in drug-screening especially by replacing animal testing (organ-on-chips), in personalized medicine (choose the right medication for each patient) and is also more and more used to understand fundamental biological processes in cell signaling or in mechanobiology. The MicroCell project is interested in the rolling of immune cells on biomimetic endothelial surfaces, in the migration of cancer cells as a function of oxygen concentration or surface and gel properties.
Articles in peer-reviewed international journals
- A. Shirai, Y. Sugiyama, J.-P. Rieu, Differentiation of neutrophil-like HL-60 cells strongly impacts their rolling on surfaces with various adhesive properties under a pressing force, Technology and Health Care 26(1) (2018) 93-108